Friday, 3rd February 28th Annual Lorne Proteomics Symposium 2023

• Measuring the Interactome of TCR-like Therapeutics - Nicola Ternette
• Steps towards utilisation of proteomic data in the cancer clinic - Roger R Reddel
• Cardiac adaptations to metabolic disease: Integrating the lipidome, proteome and metabolome - Melanie White
• Utility of quantitative proteomics in solving rare disease diagnosis - Daniella Hock

• Combining Proteomics and Metabolomics Approaches to Discover the Targets of Antimalarial Drugs - Darren J Creek
• Targeted proteome measurement of seed storage proteins across genetically diverse lupin varieties for identification of hypoallergenic varieties - Arineh Tahmasian
• Disruption of fungal cell wall carbohydrates modulates EV protein load in a pathway specific manner. - Rohan GT Lowe
• Chemoproteomic Target Deconvolution Approaches in Giardia duodenalis Using Kinase Inhibitors - Alex Lam
• Proteomic profiling of small extracellular vesicles isolated from an in vitro cell culture bioreactor simulating Mycoplasma bovis infection - Evelyne Maes

• Functional phosphoproteomic analysis of insulin signalling in ageing bone - Mriga Dutt
• Unbiased plasma proteomics of a large type 1 diabetes cohort in a mass spectrometry facility – potential, perspectives and pitfalls - Samantha Emery-Corbin
• A novel platform integrating single cell muscle physiology with single cell proteomics - Ronnie Blazev
• Exploring the phospho-immunopeptidome in haematological malignancy and their specific T cell receptors in cancer precision medicine - Kirti Pandey
• Defining the Structures and Interactions of the Human Platelet Secretome using Chemical Crosslinking - Mark Larance
• How do Greater wax moth larvae survive on a plastic diet? - Utpal Dr Bose

• Proteomic analysis of different varieties and species of rice under a range of abiotic stress conditions - Paul A. Haynes
• Are You Ready for High-throughput Single Cell Proteomics with Great Depth of Coverage - Enzo Huang
• An investigation of the physiochemical changes in field pea flour after heat treatment. - Joshua JH Hutchings
• The phospho-regulation of histone demethylases in Saccharomyces cerevisiae - Nicola M Karakatsanis
• Chemoresistant Cancer Cell Lines Are Characterized by Migratory, Amino Acid Metabolism, Protein Catabolism and IFN1 Signalling Perturbations - Manuela Klingler-Hoffmann
• Use of DIA-MS to determine the effects of storage temperature and time on FFPE tissue sections - Jennifer M. S. Koh
• A complete pipeline for human gut microbiome meta-proteomics study - Han Lee
• Development of a Novel Trabecular Bone Tissue Microarray for 20μm Resolution N-Glycan MALDI Mass Spectrometry Imaging - Yea Rin Olivia Lee
• Simulation of DIA mass spectrometry proteomics data with Synthedia - Michael G Leeming
• Supercharge Your Immunopeptidomics - Terry Lim Kam Sian
• Comparative Glycoproteomics Analysis of Different Treatments to Induce Yeast Autolysis in Sparkling Wines - Lawrence Luo
• The unfolded protein response and dynamic host subcellular proteome in response to H1N1 and H3N2 influenza virus infection - Kyle Macauslane
• Glycoprotein characterization combining native, PTCR and Direct Mass Technology mode mass spectrometry - Bruno Madio
• Stability of cytokines in dried blood spots collected using volumetric absorptive microsampling (VAMS) and stored at various temperatures. - Rosalee McMahon
• ATLANTIS – ATLas of peptide ANtigens in Transplantable tISsues - Nicole A Mifsud
• Proteome-wide systems genetics identifies UFMylation as a regulator of skeletal muscle function - Jeffrey Molendijk
• Proteomic Landscape of Human Colorectal Liver Metastasis - Mark P Molloy
• Application of shotgun proteomics techniques for characterization of proteins and peptides of tuna waste   - Mohadeseh Montazeri Shatouri
• Species identification of a collection of worked bone artefacts from Pyrmont, Australia using mass spectrometry of bone collagen - Dylan H. Multari
• Conserved T cell epitopes offer protection against highly pathogenic avian influenza A/H5N1 in South Asian populations - AKM AKMM Muraduzzaman
• Optimisation of multi-omics MALDI-MSI of lung tissue from mucopolysaccharidosis (MPS) disease murine models - Yuen Tung Ngai
• Balancing the fine act of single cell proteomics - Krishnatej Nishtala
• Dissection of glycotype and protein changes following differentiation of human induced pluripotent stem cells to cardiomyocytes - Myung Jin Oh
• Investigating the Effect of Radiotherapy on the Immunopeptidome in Colorectal Cancer - Jessica Oliver
• Inhibition of ERAP1 in cancer unmasks an alternative subset of tumour epitopes recognised by cytotoxic human CD8⁺ T cells - Wayne Paes
• Unravelling phenotypic changes in gas-fermenting acetogen Clostridium autoethanogenum through proteomics - Karen Rodriguez Martinez

Speaker: Jérémy Potriquet, Field Application Specialist, SCIEX Oceania

In recent years the speed and sensitivity of proteomic data collection and speed of processing have been steadily increasing. It is reaching the zenith of producing the quantities of data needed for the efficient training of deep learning models and unlocking the full potential of machine learning in the prediction of peptide properties, retention time, peak detection, and identification. Recent studies and observations are giving more and more confidence that increasing the rate of analysis has a limited impact on the quality of the data with the peptide-centric approach and is now creating a paradigm shift in the way we perceive and operate proteomics experiments. In this workshop, we will discuss what are the characteristics and advantages of running a fast proteomic analysis and the opportunities that it is leading to for the future of proteomics applications.

• Machine learning of cancer type and tissue of origin from proteomes of 1,277 human tissue samples and 975cancer cell lines - Qing Zhong
• The application of DIA-MS coupled with PISA TPP for drug-target deconvolution - Subash Adhikari
• Characterising the glycosylated immunopeptidome by leveraging diagnostic fragment ions using a novel spectral analysis program - Joshua Fehring
• Scaling proteomics to population size cohorts: Early insights and opportunities from ASPREE proteomics - Ahmed Mohamed