Poster Presentation 28th Annual Lorne Proteomics Symposium 2023

Pathway-Analyst: one-click proteomic knowledge generation  (#184)

Hossein HK Valipour Kahrood 1 , Joel JS Steele 1 , Ralf RS Schittenhelm 1
  1. Monash University, Clayton, VIC, Australia

The application of proteomics to complex biological questions provides a wealth of essential information on disease and functional biology. The generation of quantitative datasets provides insights into drivers of disease and the functional perturbations that occur in various biological systems. Our facility has endeavored to generate tools for the processing of complex data outputs generated by various bioinformatics programs to enable researchers' one-click solutions for enabling robust pipeline analysis that generate meaningful results. 

Our first program LFQ-Analyst offers basic insight into pathway enrichment and analysis. Here we aim to produce a new tool that aims at visualising biological information garnered from proteomic experiments. This will form a new addition to our Analyst-Suite named Pathway-Analyst, which will allow users to take lists of proteins generated in various manners, run enrichment analyses and present them in knowledge-centric figures to pull apart biological significance. We present various figures that are generated in our new tool, whereby data is queried from a diverse range of repositories and presented in customizable figures that researchers can use in publications.  Example figures include chord diagrams, UpsetR plots, Venn diagrams and annotated pathway maps.